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Fig. 1 | Experimental Hematology & Oncology

Fig. 1

From: Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases

Fig. 1

Cytogenetic, FISH and Immunophenotype results 1a G-banded karyotype from the sideline 46,XY,del(9)(p22)t(9;22)(q34;q11),del(20)(q13). 1b Metaphase FISH image showing BCR-ABL1 fusion gene at minor breakpoint BCR. Green BCR, red ABL1. 1c G-banded karyotype showing t(9;22)(q34;q11) as a sole chromosome alteration. 1d Metaphase FISH image showing BCR-ABL1 fusion gene at minor breakpoint BCR. LSI BCR/ABL1 dual color translocation probe (Abbott) was used. Green: BCR, Red: ABL1. 2a Immunophenotype of ALL with atypical e1a3 translocation. Presence of 90 % of blasts with lymphoblastic phenotype B: CD19+, CD10+, CD34+, DR+, CD20+, CD22−, CD33+, cytoplasmic IgM negative and positive alpha CD79. 2b Immunophenotype of ALL with atypical e1a3 translocation. Presence of 80 % of blasts with lymphoblastic phenotype B: CD19+, CD10+, CD34+, DR+, CD20+, CD22−, cytoplasmic IgM negative, positive alpha CD79 and dim expression of CD33

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