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Table 2 Thymus weight, caspase activity, and GSH level in mice treated with sirolimus

From: Effects of molecularly targeted therapies on murine thymus: highly selective mTOR inhibitors induce reversible thymic involution

  DMSO Sirolimus P
Mouse weight on Day 0 (g) 19.8 ± 4.3 (13) 19.0 ± 4.8 (13) 0.315
Thymus weight (mg) 39.2 ± 10.2 (13) 20.7 ± 6.9 (13) <0.001
Thymocyte respiration 0.37 ± 1.0 (6) 0.36 ± 1.0 (6) 0.937
Thymocyte GSH (nmol mg−1) 44 ± 14 (9) 82 ± 45 (9) 0.019
Thymocyte caspase activity* 28 ± 15 (9) 12 ± 9 (9) 0.019
  1. The thymus was excised from C57BL/6 mice after intraperitoneal treatments with DMSO (0.5 µL/g on Days 0–3) or sirolimus (2.5 µg/g on Days 0–3). On Day 4, the weight of the entire gland was measured and fragments of the gland were processed for measuring cellular respiration, caspase activity and GSH level as described in “Methods” section
  2. Expressed as µM O2 min−1 mg−1
  3. * Expressed as AMC peak area (in arbitrary unit ÷103) mg−1