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Table 1 In vitro effects of the studied drugs on thymocyte respiration

From: Effects of molecularly targeted therapies on murine thymus: highly selective mTOR inhibitors induce reversible thymic involution

  Drug concentration (µM) k c (µM O2 min−1 mg−1) Inhibition (%) P
Sirolimus (mTOR inhibitor) 0 0.39 ± 0.10 (12)
10 0.29 ± 0.07 (10) 26 0.007
Everolimus (mTOR inhibitor) 0 0.46 ± 0.14 (20)
10 0.33 ± 0.13 (19) 28 0.002
BEZ235 (PI3 K/mTOR inhibitor) 0 0.44 ± 0.13 (12)
10 0.35 ± 0.16 (12) 16 0.045
GDC0980 (PI3 K/mTOR inhibitor) 0 0.48 ± 0.11 (12)
10 0.40 ± 0.08 (12) 17 0.089
GSK2126458 (PI3 K/mTOR inhibitor) 0 0.53 ± 0.16 (11)
10 0.45 ± 0.13 (11) 15 0.193
Idelalisib (P110δ inhibitor) 0 0.44 ± 0.19 (7)
10 0.48 ± 0.14 (8) 0 0.336
Tacrolimus (Calcineurin inhibitor) 0 0.41 ± 0.12 (12)
10 0.45 ± 0.10 (12) 0 0.755
  1. For each run, the thymus was excised from a C57BL/6 mouse, and a fragment of the gland was immediately placed in the oxygen-measuring vial for determining the rate of cellular respiration in the presence of DMSO or designated drug
  2. The values of k c are mean ± SD. The values in parentheses are number of mice (equal to number of O2 runs)