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Table 1 In vitro effects of the studied drugs on thymocyte respiration

From: Effects of molecularly targeted therapies on murine thymus: highly selective mTOR inhibitors induce reversible thymic involution

 

Drug concentration (µM)

k c (µM O2 min−1 mg−1)

Inhibition (%)

P

Sirolimus (mTOR inhibitor)

0

0.39 ± 0.10 (12)

10

0.29 ± 0.07 (10)

26

0.007

Everolimus (mTOR inhibitor)

0

0.46 ± 0.14 (20)

10

0.33 ± 0.13 (19)

28

0.002

BEZ235 (PI3 K/mTOR inhibitor)

0

0.44 ± 0.13 (12)

10

0.35 ± 0.16 (12)

16

0.045

GDC0980 (PI3 K/mTOR inhibitor)

0

0.48 ± 0.11 (12)

10

0.40 ± 0.08 (12)

17

0.089

GSK2126458 (PI3 K/mTOR inhibitor)

0

0.53 ± 0.16 (11)

10

0.45 ± 0.13 (11)

15

0.193

Idelalisib (P110δ inhibitor)

0

0.44 ± 0.19 (7)

10

0.48 ± 0.14 (8)

0

0.336

Tacrolimus (Calcineurin inhibitor)

0

0.41 ± 0.12 (12)

10

0.45 ± 0.10 (12)

0

0.755

  1. For each run, the thymus was excised from a C57BL/6 mouse, and a fragment of the gland was immediately placed in the oxygen-measuring vial for determining the rate of cellular respiration in the presence of DMSO or designated drug
  2. The values of k c are mean ± SD. The values in parentheses are number of mice (equal to number of O2 runs)