Drug concentration (µM) | k c (µM O2 min−1 mg−1) | Inhibition (%) | P | |
---|---|---|---|---|
Sirolimus (mTOR inhibitor) | 0 | 0.39 ± 0.10 (12) | – | – |
10 | 0.29 ± 0.07 (10) | 26 | 0.007 | |
Everolimus (mTOR inhibitor) | 0 | 0.46 ± 0.14 (20) | – | – |
10 | 0.33 ± 0.13 (19) | 28 | 0.002 | |
BEZ235 (PI3 K/mTOR inhibitor) | 0 | 0.44 ± 0.13 (12) | – | – |
10 | 0.35 ± 0.16 (12) | 16 | 0.045 | |
GDC0980 (PI3 K/mTOR inhibitor) | 0 | 0.48 ± 0.11 (12) | – | – |
10 | 0.40 ± 0.08 (12) | 17 | 0.089 | |
GSK2126458 (PI3 K/mTOR inhibitor) | 0 | 0.53 ± 0.16 (11) | – | – |
10 | 0.45 ± 0.13 (11) | 15 | 0.193 | |
Idelalisib (P110δ inhibitor) | 0 | 0.44 ± 0.19 (7) | – | – |
10 | 0.48 ± 0.14 (8) | 0 | 0.336 | |
Tacrolimus (Calcineurin inhibitor) | 0 | 0.41 ± 0.12 (12) | – | – |
10 | 0.45 ± 0.10 (12) | 0 | 0.755 |