Fig. 3

Effects of systemic sorafenib and idelalisib treatments on thymus histology and immunoperoxidase staining with cytochrome c (Day 4). Mice received intraperitoneal DMSO, sorafenib or idelalisib on Days 0–3. Thymus fragments were then stained with H&E and immunoperoxidase with anti-cytochrome c on Day 4. Normal thymus histology with a cortex rich in lymphocytes and a lymphocyte scant medulla; few (<2 %) cortical lymphocytes with positive staining for cytochrome c are present