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Table 1 Pathologic Features of EBVMCU

From: Diagnostic and therapeutic challenges of EBV-positive mucocutaneous ulcer: a case report and systematic review of the literature

Histology Immunophenotype
Shallow, sharply circumscribed ulcers Immunoblasts often with HRS features:
 strong positivity for CD10, CD30, MUM1
 uniform positivity for PAX5 and OCT-2
 variable expression of CD20, CD45, CD15, CD79a, BCL-6, BOB.1
Localized to mucosa of oropharynx and gastrointestinal tract or to skin Infiltrating lymphocytes:
 CD4 and CD8 positivity
Polymorphous infiltrate of lymphocytes and immunoblasts Clonality
Variable admixture of scattered plasma cells, eosinophils, and histiocytes Immunoblasts with HRS features:
 monoclonal immunoglobulin rearrangement
Medium sized lymphocytes with angulated nuclei Infiltrating T-lymphocytes:
 frequent monoclonal or restricted TCR pattern
Pleomorphic immunoblasts with frequent Hodgkin and Reed-Sternberg (HRS) morphology Association with EBV
Plasmacytoid apoptotic cells Immunoblasts and HRS cells:
 uniformly EBER1-positive
Variable angioinvasion Infiltrating T-lymphocytes:
 frequently EBER1-positive
Variable tissue necrosis Plasmacytoid apoptotic cells:
 uniformly EBER1-postive