TY - JOUR AU - Panagopoulos, Ioannis AU - Gorunova, Ludmila AU - Kerndrup, Gitte AU - Spetalen, Signe AU - Tierens, Anne AU - Osnes, Liv T. N. AU - Andersen, Kristin AU - Müller, Lil-Sofie Ording AU - Hellebostad, Marit AU - Zeller, Bernward AU - Heim, Sverre PY - 2016 DA - 2016/03/05 TI - Rare MLL-ELL fusion transcripts in childhood acute myeloid leukemia—association with young age and myeloid sarcomas? JO - Experimental Hematology & Oncology SP - 8 VL - 5 IS - 1 AB - The chromosomal translocation t(11;19)(q23;p13) with a breakpoint within subband 19p13.1 is found mainly in acute myeloid leukemia (AML) and results in the MLL-ELL fusion gene. Variations in the structure of MLL-ELL seem to influence the leukemogenic potency of the fusion in vivo and may lie behind differences in clinical features. The number of cases reported so far is very limited and the addition of more information about MLL-ELL variants is essential if the possible clinical significance of rare fusions is to be determined. SN - 2162-3619 UR - https://doi.org/10.1186/s40164-016-0037-2 DO - 10.1186/s40164-016-0037-2 ID - Panagopoulos2016 ER -