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Fig. 3 | Experimental Hematology & Oncology

Fig. 3

From: New CD20 alternative splice variants: molecular identification and differential expression within hematological B cell malignancies

Fig. 3

Alternative CD20-transcripts, putative proteins and junction characterization. a Schematic representation of CD20 variant coding transcripts. Transmembrane domains (TM) are positioned on the linear N-ter/C-ter protein, as well as position of the main clinical anti-CD20 antibody epitopes. Rituximab (gray line), Ofatumumab (blue line) and Obinutuzumab (red line). Schematic representation of antibody recognition on the putative CD20 variant-proteins. AA position is provided and numbered from the first ATG (Met) start codon. b Schematic reconstitution of amino acidic (AA) junction area after splicing involving canonical (closed boxes) or cryptic (open boxes) splice. AA sequence flanking junction is provided as well as AA position

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Experimental Hematology & Oncology

ISSN: 2162-3619

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