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Table 1 Relative expression of Transcription coupled repair (TCR) and nucleotide excision repair (NER) transcripts in melanocytes and melanoma cell lines following UVA

From: Nucleotide excision repair deficiency in melanoma in response to UVA

Gene Cell Type Time (h)
0 1 4 24 48
RE P value RE P value RE P value RE P value RE P value
Transcription coupled repair (TCR)
 ERCC6 Melanocytes 0.0883 NS 0.0000 <0.001 0.1079 NS 0.0236 <0.001 0.3084 NS
Melanoma 0.1345 0.1003 0.1534 0.1715 0.2396
 ERCC8 Melanocytes 0.0893 NS 0.0000 <0.001 0.1026 NS 0.0251 <0.001 0.1102 NS
Melanoma 0.1707 0.0586 0.0780 0.0482 0.0980
Nucleotide excision repair (NER)
 XPA Melanocytes 0.1288 0.03 0.2592 <0.001 0.5513 <0.001 0.1530 NS 0.5681 NS
Melanoma 0.0924 0.1161 0.1447 0.2406 0.3585
 RPA1 Melanocytes 0.4713 0.02 0.3281 <0.001 1.1675 NS 0.9926 0.038 4.1019 NS
Melanoma 2.0848 1.3489 0.9849 2.4304 2.1699
 RPA2 Melanocytes 0.2883 0.002 0.4576 0.002 1.3346 NS 0.4085 <0.001 1.5100 NS
Melanoma 1.7746 1.2359 1.2400 1.9103 1.6426
 ERCC1 Melanocytes 1.1466 NS 1.2102 NS 4.1937 <0.001 6.4460 <0.001 3.0374 0.04
Melanoma 1.1916 1.4276 1.5437 1.5859 2.2263
 ERCC2 Melanocytes 0.6308 NS 0.9042 0.007 1.7292 <0.001 0.8925 <0.001 1.1017 0.03
Melanoma 0.5406 0.4764 0.3694 0.4094 0.5468
 ERCC3 Melanocytes 0.1390 <0.001 0.7994 NS 0.8556 <0.001 0.2262 <0.001 1.0353 0.05
Melanoma 0.4889 0.4753 0.3632 0.6632 0.6733
 ERCC4 Melanocytes 0.1018 NS 0.0000 <0.001 0.1832 0.009 0.0000 <0.001 0.4600 NS
Melanoma 0.1977 0.1656 0.1709 0.2446 0.3675
 ERCC5 Melanocytes 0.0537 0.001 0.0000 <0.001 0.1138 NS 0.0000 <0.001 0.4116 NS
Melanoma 0.2245 0.2294 0.1160 0.2777 0.3699