Nucleotide excision repair deficiency in melanoma in response to UVA

Table 1 Relative expression of Transcription coupled repair (TCR) and nucleotide excision repair (NER) transcripts in melanocytes and melanoma cell lines following UVA

Gene	Cell Type	Time (h)
		0		1		4		24		48
		RE	P value	RE	P value	RE	P value	RE	P value	RE	P value
Transcription coupled repair (TCR)
ERCC6	Melanocytes	0.0883	NS	0.0000	<0.001	0.1079	NS	0.0236	<0.001	0.3084	NS
ERCC6	Melanoma	0.1345	NS	0.1003	<0.001	0.1534	NS	0.1715	<0.001	0.2396	NS
ERCC8	Melanocytes	0.0893	NS	0.0000	<0.001	0.1026	NS	0.0251	<0.001	0.1102	NS
ERCC8	Melanoma	0.1707	NS	0.0586	<0.001	0.0780	NS	0.0482	<0.001	0.0980	NS
Nucleotide excision repair (NER)
XPA	Melanocytes	0.1288	0.03	0.2592	<0.001	0.5513	<0.001	0.1530	NS	0.5681	NS
XPA	Melanoma	0.0924	0.03	0.1161	<0.001	0.1447	<0.001	0.2406	NS	0.3585	NS
RPA1	Melanocytes	0.4713	0.02	0.3281	<0.001	1.1675	NS	0.9926	0.038	4.1019	NS
RPA1	Melanoma	2.0848	0.02	1.3489	<0.001	0.9849	NS	2.4304	0.038	2.1699	NS
RPA2	Melanocytes	0.2883	0.002	0.4576	0.002	1.3346	NS	0.4085	<0.001	1.5100	NS
RPA2	Melanoma	1.7746	0.002	1.2359	0.002	1.2400	NS	1.9103	<0.001	1.6426	NS
ERCC1	Melanocytes	1.1466	NS	1.2102	NS	4.1937	<0.001	6.4460	<0.001	3.0374	0.04
ERCC1	Melanoma	1.1916	NS	1.4276	NS	1.5437	<0.001	1.5859	<0.001	2.2263	0.04
ERCC2	Melanocytes	0.6308	NS	0.9042	0.007	1.7292	<0.001	0.8925	<0.001	1.1017	0.03
ERCC2	Melanoma	0.5406	NS	0.4764	0.007	0.3694	<0.001	0.4094	<0.001	0.5468	0.03
ERCC3	Melanocytes	0.1390	<0.001	0.7994	NS	0.8556	<0.001	0.2262	<0.001	1.0353	0.05
ERCC3	Melanoma	0.4889	<0.001	0.4753	NS	0.3632	<0.001	0.6632	<0.001	0.6733	0.05
ERCC4	Melanocytes	0.1018	NS	0.0000	<0.001	0.1832	0.009	0.0000	<0.001	0.4600	NS
ERCC4	Melanoma	0.1977	NS	0.1656	<0.001	0.1709	0.009	0.2446	<0.001	0.3675	NS
ERCC5	Melanocytes	0.0537	0.001	0.0000	<0.001	0.1138	NS	0.0000	<0.001	0.4116	NS
ERCC5	Melanoma	0.2245	0.001	0.2294	<0.001	0.1160	NS	0.2777	<0.001	0.3699	NS

ISSN: 2162-3619