Fig. 3
From: Nucleotide excision repair deficiency in melanoma in response to UVA
Expression of global genome repair XPC, DDB1, and DDB2 following UVA irradiation in melanocytes and melanoma. Cell lines were irradiated with 100 kJ/m2 UVA, then mRNA transcript relative expression (RE) at baseline and 1, 4, 24, and 48 h post-irradiation was determined. a RE of XPC mRNA transcript b DDB1 mRNA transcript, c DDB2 mRNA transcript. Significance compared to melanocytes (HEMaLP) determined by Mann–Whitney U test. *p < 0.05. Points mean of triplicate determinations of three independent experiments; bars ± SEM. d Western blot of XPC, DDB1 and DDB2 for all cell lines before and after UVA. Blots are representative of duplicate blots run for all proteins and cell lines