Sign, symptom, or event, n (%) | Currently using HU therapy (n = 1080) | Discontinued HU therapy (n = 229) |
---|---|---|
Fatigue or tiredness | 304 (28.1) | 74 (32.3) |
Splenomegaly | 267 (24.7) | 60 (26.2) |
Plethora | 138 (12.8) | 27 (11.8) |
Dizziness | 112 (10.4) | 41 (17.9)* |
Headache | 108 (10.0) | 23 (10.0) |
Abdominal discomfort/pain | 106 (9.8) | 39 (17.0)* |
Hepatomegaly | 103 (9.5) | 27 (11.8) |
Pruritus | 96 (8.9) | 23 (10.0) |
Feeling of fullness | 89 (8.2) | 28 (12.2) |
Thrombotic eventsa | 64 (5.9) | 11 (4.8) |
Cardiovascular problems | 52 (4.8) | 14 (6.1) |
Bone pain | 43 (4.0) | 16 (7.0)* |
Anemia | 28 (2.6) | 13 (5.7)* |
Thrombophlebitis | 24 (2.2) | 3 (1.3) |
Thrombosis | 22 (2.0) | 2 (0.9) |
Neutropenia | 21 (1.9) | 3 (1.3) |
Thrombocytopenia | 14 (1.3) | 4 (1.8) |
Stroke/TIA | 18 (1.7) | 5 (2.2) |
Pulmonary embolism | 7 (0.6) | 1 (0.4) |
Cancer | 5 (0.5) | 0 |
Elevation in blasts | 2 (2.1) | 4 (1.8) |
Unknown | 21 (1.9) | 12 (5.2)* |
No new symptoms | 471 (43.6) | 91 (39.7) |