Fig. 1
From: GATA family transcriptional factors: emerging suspects in hematologic disorders
The full length GATA1 protein contains a solitary “N terminal activation domain” (AD) and the two Zinc finger domains (N-ZF, C-ZF). The N terminal zinc finger interacts with cofactor FOG1 and increase the binding affinity to complex DNA motifs. The C terminal zinc finger binds to specific DNA motif “WGATAR”. The short isoform GATA1 protein is the transcriptional product from the shorter splice variant which results in the absence of “N terminal activation domain”. GATA2 and GATA3 encode full length proteins contain two transactivation domains (TA1 and TA2) which contain binding sites for other proteins such as transcription coregulators. The N-terminal Zn finger (N-ZF1) is known to stabilize DNA binding and interact with other zinc finger proteins, whereas the C-terminal Zn finger (C-ZF) binds DNA