Tissue factor-dependent and -independent pathways of systemic coagulation activation in acute myeloid leukemia: a single-center cohort study

Table 2 Characteristics of patients with decompensated DIC at presentation

No.	AML subtype	Age (years)	Sex	PB (10³/µL)	Platelets (10³/µL)	Fg (g/L)	D-dimer (mg/L)	TF PCA (AU/10⁶ cells)	MP TF PCA	TF antigen (pg/mL)	DNA (ng/mL)	LDH (U/L)	Clinical outcome
1	M1	74	♀	287	25	0.8	36.2	1,483	No	n. d.	n. d.	924	Deceased after 3 days (fatal PE)
2	M3 (APL)	61	♀	97	14	0.8	26.4	6,141	Yes	n. d.	n. d.	n.d.	Deceased after 2 days (fatal ICH)
3	M5	69	♂	1	114	0.3	32.9	9,939	n. d.	32	220	1,663	Deceased after 4.3 months
4	M3 (APL)	56	♂	6	36	0.6	35.1	4,045	Yes	101	77	1,881	Alive at 69 months follow-up
5	M5	73	♂	1	43	0.6	34.1	11,070	No	40	38,716	6,841	Deceased after 6 days (fatal ACS)
6	M1	74	♀	40	88	0.6	22.1	4,515	Yes	115	1,513	1,409	Alive at 23 months follow-up
7	M2	69	♀	79	80	0.9	35.4	515	Yes	72	222	566	Alive at 52 months follow-up
8	M3 (APL)	47	♂	1	21	1.0	35.4	22,779	Yes	43	344	429	Deceased after 2.9 months (fatal pneumonia)
9	M3 (APL)	39	♀	89	25	0.8	21.3	1,693	n. d.	n. d.	n. d.	3,072	Deceased after 5 days (fatal ICH)
10	M2	70	♂	39	51	0.6	34.0	2,537	Yes	76	3,086	1,444	Deceased after 8.3 months
11	M4	21	♂	115	61	1.0	34.0	5,926	No	141	450	2,140	Deceased after 4.4 months (recurrent AML with DIC)

Tissue factor procoagulant activity (TF PCA), expressed as arbitrary units (AU), is of intact peripheral blood mononuclear cells. Reference ranges are as follows: platelets, 150–400 × 10³/µL; fibrinogen, 1.8–4.0 g/L; D-dimer, 0–0.5 mg/L; LDH, 84–246 U/L.
ACS acute coronary syndrome, APL acute promyelocytic leukemia, Fg fibrinogen, ICH intracerebral hemorrhage, LDH lactate dehydrogenase, MP microparticle, PE pulmonary embolism, PB peripheral blasts.

ISSN: 2162-3619