Fig. 2

Correlations of PBMC-associated TF PCA, circulating blasts, and serum lactate dehydrogenase (LDH) with plasma D-dimer. Cellular TF PCA was measured by single-stage clotting assay using both intact (a) and disrupted PBMCs (b). Absolute numbers of circulating blasts (c) were calculated by multiplying the automatically determined white blood cell count with the percentage of myeloblasts on peripheral blood smears. LDH serum levels (d) were determined by standard laboratory techniques. Correlation coefficients and P values are according to the method of Spearman. The horizontal dashed lines in panels a and b indicate thresholds above which TF PCA levels were inevitably associated with decompensated DIC and a (thrombo)hemorrhagic syndrome as observed in eleven patients (red data points). The LDH serum level was not available from one patient with DIC.