Fig. 2

Kinome profile in Philadelphia chromosome negative pediatric BCP-ALL patients. a Unsupervised hierarchical clustering of 45 pediatric BCP-ALL cases; 13 IKZF1 deleted, 1 IKZF1 gain, and 31 IKZF1 wild type Philadelphia chromosome negative patients based on 1,008 unique target peptides. No distinct clustering could be observed based on IKZF1 status, neither on genetic background or other copy number alterations. b Unsupervised hierarchical clustering of 44 pediatric BCP-ALL cases; 13 IKZF1 deleted and 31 IKZF1 wild type patients based on 38 differentially phosphorylated peptides identified by t test. Each row represents a peptide, each column represents a single ALL sample. The magnitude of deviation from the median is represented by the color saturation with each variable normalized to mean 0 and variance 1. Red and green spots display the phosphorylation intensity above and below the median, respectively.