Fig. 6

Efficiacy of Syk inhibition on cell viability is not reduced in the presence of Il-6. To determine the impact of IL-6 on the apoptotic effects of Syk inhibitors, MM cells were preincubated with IL-6 and nuclear fragmentation of MM cells treated with Syk inhibitors was measured by flow cytometry. In comparison with Bay61-3606 or Piceatannol alone, a combination with IL-6 did not reduce significantly the number of apoptotic cells. Results are expressed as the mean of three panels per pattern. Results are from one experiment representative of three. DMSO was used as control. The significance is related to DMSO. ⁺P<1.000, *P < 0.1, **P < 0.01, ***P < 0.001.