Immunohistochemical analysis indicates that the anatomical location of B-cell non-Hodgkin’s lymphoma is determined by differentially expressed chemokine receptors, sphingosine-1-phosphate receptors and integrins

Table 1 Expression of molecules involved in lymphocyte trafficking

A. Anatomical sites
Lymphoma subtype	Entry into SLO			Entry into extranodal tissues			Retention in tissues			Egress
	CCR7	CCL21	αL	CXCR4	CXCL12	α4	CXCR5	CXCL13	S1PR2	S1PR1	S1PR3
SLO	±	+++	+	++	±	+	++	±	+++	±	+
OAL	±	+	+++	+++	+	+++	+++	+	-	±	++
LL	+		±	±		±	±		-	+++	NA
B. Histological features
Lymphoma subtype	Entry into SLO			Entry into extranodal tissues			Retention in tissues			Egress
	CCR7	CCL21	αL	CXCR4	CXCL12	α4	CXCR5	CXCL13	S1PR2	S1PR1	S1PR3*
FL	±	+++	+	+	+	++	++	+	±	±	+
MZL	±	+++	++	+++	+	++	++	+	-	+	+
DLBCL	±	+++	+	++	+	++	+++	+	++	-	+
MCL	±	+++	±	++	-	++	++	+	±	++	+

Expression is based on the median staining scores: 0–1 (−); >1-2 (±); >2-4 (+); >4-6 (++); >6 (+++). SLO - secondary lymphoid organ; OAL – ocular adnexal lymphoma; LL - leukaemic lymphoma; NA - not available.

ISSN: 2162-3619