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Table 1 Ibrutinib in clinical trials for chronic lymphoid leukemia

From: Ibrutinib for B cell malignancies

Studies Phase Ib/II for CLL/SLL Phase Ib/II for CLL patients (N=116) [26] Ibrutinib Ibrutinib
+ +
      Rituximab Ofatumumab
  (High risk refractory/relapsed) Treatment naïve patients >65 years old Relapsed/refractory High risk relapsed/refractory (Relapsed/refractory CLL) (Relapsed/refractory CLL)
  [N=85] [24]     [N=40] [40] [N=40] [41]
ORR 71% 71% (CR=10%, PR=61%) 67 % (CR=3%, PR=64%) 50% (PR=50%, CR=0%) 85% 100%
  1. ORR = overall response rate; CR = complete remission; PR = partial remission.