Figure 3From: The effect of metronomic versus standard chemotherapy on the regulatory to effector T-cell equilibrium in cancer patients Metronomic chemotherapy affects the number and function of Tregs. (A) Teff proliferation was measured by the cell proliferation assay and expressed as mean optical densities (OD) at 450 nm ± SE. Teffs, single cultures of Teffs; Teffs + Tregs, co-cultures of Teffs with autologous Tregs at a ratio 4:1. (B) Treg-induced suppression of Teff proliferation. Shown are mean % values ± SE. Pre-CTx, patients before chemotherapy administration. All samples were analyzed in triplicates. * p < 0.05, ** p < 0.01, as estimated by paired-t test.Back to article page