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Table 3 COX proportional hazard model- time to death

From: Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC: is there evidence to support a prognostic or diagnostic role?

  

Unadjusted HR

Adjusted HR

  

HR

95% CI

P

HR

95% CI

P

pAkt S473

Overall

  

0.168

  

0.005

 

Med:No

6.27

0.87, 45.3

0.069

438

10.9, 1755

0.001

 

Med:Low

1.83

0.38, 8.88

0.456

21.5

1.23, 376

0.036

Tumor size

T3/T4:T1/T2

4.59

1.39, 15.2

0.013

15.2

2.28, 102

0.005

Alcohol

Overall

  

0.005

  

0.021

 

Heavy:Non-drinker

15.4

2.74, 86.7

0.002

49.4

3.04, 801

0.006

 

Heavy:Moderate

3.19

0.62, 16.5

0.166

2.69

0.35, 20.8

0.343

Age

≥65:<65

5.41

1.17, 25.05

0.031

46.8

2.81, 781

0.007

HPV

+ve:-ve

   

89.4

4.05, 1973

0.004

Gender

F:M

1.40

0.42, 4.63

0.581

   

Tumor size

Overall

  

0.310

   

Nodal status

+ve: -ve

1.49

0.43, 5.10

0.529

   

Smoking

No:Yes

1.45

0.42, 4.95

0.556

   

pAkt T308

Overall

  

0.984

   
 

Low:High

1.02

0.21, 4.92

0.985

   
 

Med:High

1.16

0.24, 5.63

0.858

   
  1. Note: Unadjusted HR obtained from univariable analysis and adjusted HR from multivariable analysis after adjusting tumor size, alcohol, age, HPV and pAkt S473. All the variables are categorical and HR = exp (B). Abbreviations: HR Hazard ratio, 95% CI 95% confidence interval.
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Experimental Hematology & Oncology

ISSN: 2162-3619

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