Skip to main content

Table 3 COX proportional hazard model- time to death

From: Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC: is there evidence to support a prognostic or diagnostic role?

   Unadjusted HR Adjusted HR
   HR 95% CI P HR 95% CI P
pAkt S473 Overall    0.168    0.005
  Med:No 6.27 0.87, 45.3 0.069 438 10.9, 1755 0.001
  Med:Low 1.83 0.38, 8.88 0.456 21.5 1.23, 376 0.036
Tumor size T3/T4:T1/T2 4.59 1.39, 15.2 0.013 15.2 2.28, 102 0.005
Alcohol Overall    0.005    0.021
  Heavy:Non-drinker 15.4 2.74, 86.7 0.002 49.4 3.04, 801 0.006
  Heavy:Moderate 3.19 0.62, 16.5 0.166 2.69 0.35, 20.8 0.343
Age ≥65:<65 5.41 1.17, 25.05 0.031 46.8 2.81, 781 0.007
HPV +ve:-ve     89.4 4.05, 1973 0.004
Gender F:M 1.40 0.42, 4.63 0.581    
Tumor size Overall    0.310    
Nodal status +ve: -ve 1.49 0.43, 5.10 0.529    
Smoking No:Yes 1.45 0.42, 4.95 0.556    
pAkt T308 Overall    0.984    
  Low:High 1.02 0.21, 4.92 0.985    
  Med:High 1.16 0.24, 5.63 0.858    
  1. Note: Unadjusted HR obtained from univariable analysis and adjusted HR from multivariable analysis after adjusting tumor size, alcohol, age, HPV and pAkt S473. All the variables are categorical and HR = exp (B). Abbreviations: HR Hazard ratio, 95% CI 95% confidence interval.