Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC: is there evidence to support a prognostic or diagnostic role?

Table 1 Demographic, behavioral and pathological data by pAkt status

		Akt T308 phosphorylation status				Akt S473 phosphorylation status
	n	High	Medium	Low	p	Medium	Low	None	p
		(n = 40)	(n = 8)	(n = 10)		(n = 5)	(n = 30)	(n = 23)
		%	%	%		%	%	%
Gender					0.109				0.737
Male	33	62	63	30		60	50	65
Female	25	38	37	70		40	50	35
Age					0.233				0.376
<65 years	30	50	50	60		80	43	57
≥65 years	28	50	50	40		20	57	43
Location					0.217				0.094
FOM	10	15	25	20		20	17	17
RMT	8	10	13	30		0	10	22
SP	5	10	0	10		40	10	0
Tong	27	53	50	20		20	47	53
Alv	4	5	0	20		0	10	4
Other	4	7	12	0		20	6	4
Tumor size					0.173				0.213
T1-T2	43	70	25	90		60	73	78
T3-T4	15	30	75	10		40	27	22
Grade					0.523				0.788
I	5	8	12	10		0	7	13
II	39	65	75	70		80	66	65
III	14	27	13	20		20	27	22
Lymph node metastasis					0.018				0.327
Positive	27	58	12	30		40	50	43
Negative	31	42	88	70		60	50	57
HPV status					0.028				0.301
Positive	29	40	63	80		40	43	61
Negative	29	60	37	20		60	57	39
Smoking					0.022				0.449
Yes	42	82	50	50		80	70	74
No	16	18	50	50		20	30	26
Alcohol					0.027				0.968
Non-drinker	7	10	0	30		0	17	9
Medium drinker	21	27	62	40		40	33	39
Heavy drinker	30	63	38	30		60	50	52

Note: The General linear model was used for hypothesis testing of the relationship between different variables and pAkt. The P value was obtained from univariable analysis. Percentages represent the column percentages within variable so that the balance between the pAkt groups could be assessed. Abbreviations: FOM Floor of the mouth, RMT Retromolar trigone, SP Soft palate, Tong Tongue, Alv Alveolus.

ISSN: 2162-3619