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Table 1 Demographic, behavioral and pathological data by pAkt status

From: Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC: is there evidence to support a prognostic or diagnostic role?

   Akt T308 phosphorylation status Akt S473 phosphorylation status
n High Medium Low p Medium Low None p
(n = 40) (n = 8) (n = 10) (n = 5) (n = 30) (n = 23)
% % % % % %
Gender      0.109     0.737
Male 33 62 63 30 60 50 65
Female 25 38 37 70 40 50 35
Age      0.233     0.376
<65 years 30 50 50 60 80 43 57
≥65 years 28 50 50 40 20 57 43
Location      0.217     0.094
FOM 10 15 25 20 20 17 17
RMT 8 10 13 30 0 10 22
SP 5 10 0 10 40 10 0
Tong 27 53 50 20 20 47 53
Alv 4 5 0 20 0 10 4
Other 4 7 12 0 20 6 4
Tumor size      0.173     0.213
T1-T2 43 70 25 90 60 73 78
T3-T4 15 30 75 10 40 27 22
Grade      0.523     0.788
I 5 8 12 10   0 7 13
II 39 65 75 70   80 66 65
III 14 27 13 20   20 27 22
Lymph node metastasis      0.018     0.327
Positive 27 58 12 30 40 50 43
Negative 31 42 88 70 60 50 57
HPV status      0.028     0.301
Positive 29 40 63 80 40 43 61
Negative 29 60 37 20 60 57 39
Smoking      0.022     0.449
Yes 42 82 50 50 80 70 74
No 16 18 50 50 20 30 26
Alcohol      0.027     0.968
Non-drinker 7 10 0 30 0 17 9
Medium drinker 21 27 62 40 40 33 39
Heavy drinker 30 63 38 30 60 50 52
  1. Note: The General linear model was used for hypothesis testing of the relationship between different variables and pAkt. The P value was obtained from univariable analysis. Percentages represent the column percentages within variable so that the balance between the pAkt groups could be assessed. Abbreviations: FOM Floor of the mouth, RMT Retromolar trigone, SP Soft palate, Tong Tongue, Alv Alveolus.