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Figure 3 | Experimental Hematology & Oncology

Figure 3

From: Childhood B-acute lymphoblastic leukemia: a genetic update

Figure 3

Evaluation of a 2 year-old girl presenting with fevers. A. Bone marrow core biopsy (100×) showing sheets of round to oval lymphoblasts. B. Bone marrow aspirate (100×) showing lymphoblasts with cytoplasmic vacuoles. C. Representative flow cytometry histogram. The CD45(dim) gated population contained excess B-lymphoblasts (81% of total), positive for CD10, CD19, CD34, CD38, CD79a, HLA-DR, and TdT. D. Abnormal female karyotype with unbalanced rearrangements of 1p, a derivative chromosome 12 (due to an unbalanced translocation between chromosomes 1p and 12p), and a derivative chromosome 21 (due to an unbalanced translocation between chromosomes 12 and 21), resulting in ETV6-RUNX1 fusion. E-F. Abnormal FISH signal pattern consistent with ETV6-RUNX1 (TEL-AML1) fusion, indicative of t(12;21) translocation.

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