From: Circulating MicroRNAs in gynecological malignancies: from detection to prediction
Dysregulated microRNAs | Associations | Histology | Sources | Methods | References | |
---|---|---|---|---|---|---|
Up-regulated | Down-regulated | |||||
miR-21, 29a, 92, 93, 126 | miR-127, 155, 99b | Â | ovarian cancer | serum, patient vs. normal control | microarray,qRT-PCR | Resnick, 2009 [14] |
95 miRNAs | 88 miRNAs, 4 validated by qRT-PCR: miR-132, 26a, let-7b, miR-145 | Â | serous ovarian cancer | serum, patient vs. healthy control | microarray,qRT-PCR | Chung, 2013 [15] |
miR-205, 643, 200a, 184, 9, 21*, let-7f-2*, miR-483-5p, 616*, 34a*, 501-5p, 141 | let-7a, 7d*, 7e*, 106b*, 149, 193b*, 362-3p, 363*, 422a, 449a, 770-5p, 98, 15b*, let-7f, miR-221, 450a, 570, 573 | lower let-7f vs. poor prognosis | epithelial ovarian cancer | plasma, patient vs. healthy control | TaqMan Low Density Array, qRT-PCR | Zheng, 2013 [18] |
miR-1274a, 30b, 30c, 625-3p, 720; | Â | serous epithelial ovarian cancer | plasma, OC# patient vs. healthy volunteer | TaqMan Open Array | Â | |
miR-106b, 126, 150, 17, 20a, 92a; | Â | plasma, OC# patient vs. benign neoplasm | Shapira, 2014 [16] | |||
MiR-139-5p, 142-3p, 484, 486, 660 | Â | benign neoplasm vs. healthy volunteer | ||||
miR-21, 191, 16, 15b, 1977, 1979, 1973, 1974, 4284, 195; | Â | EAOC##: endometrioidand/or clear cell adenocarcinoma | plasma, EAOC patients vs. healthy controls | RT-qPCR | Suryawanshi, 2013 [17] | |
miR-362-5p, 1274a, 21, 766, 1975, 1308, 191, 744, 376a, 1246; | Â | plasma, EAOC patients vs. endometriosis patients | ||||
miR-16, 195, 191, 1974, 4284, 15b, 1978, 1979, 362-5p, 1973 | Â | endometriosis patients vs. healthy controls |