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Figure 2 | Experimental Hematology & Oncology

Figure 2

From: Cohesin mutations in myeloid malignancies: underlying mechanisms

Figure 2

Cohesin regulates gene expression by controlling CRE-promoter interactions. CREs can regulate gene expression by physically contacting a promoter, but are often located at a distance (tens of kilobases and sometimes megabases) from the promoter. Cohesin is involved in the establishment and maintenance of CRE-promoter interactions and can thereby control gene expression. Loss of cohesin can lead to loss of CRE-promoter interactions, resulting in inappropriate gene repression, or gene activation.

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