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Figure 1 | Experimental Hematology & Oncology

Figure 1

From: Cohesin mutations in myeloid malignancies: underlying mechanisms

Figure 1

Frequency of cohesin mutations in AML. Cohesin is a multi-subunit protein complex that is involved in chromosome pairing, DNA repair and transcription regulation. Mutations within the individual protein components of cohesin occur at significant frequency in AML. Data from references 20–28 were combined to determine the mutation frequency (boxes) in each of the cohesin subunits (SMC1A, SMC3, STAG1/2, and RAD21). Details of mutations found in each study are presented in Table S1.

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