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Table 4 Comparison of various calretinin and CK5/6 diagnostic criteria for cholangiocarcinoma

From: Expression and diagnostic values of calretinin and CK5/6 in cholangiocarcinoma

No.

Criteria

CC

Total CC

Sensitivity

P value*

NBD

Total NBD

Specificity

P value*

1

Cal 1+

12

23

52.17%

0.227

23

23

100.00%

NA

2

Cal 2+

8

23

34.78%

0.018

23

23

100.00%

NA

3

Cal 3+

4

23

17.39%

<0.001#

23

23

100.00%

NA

4

CK5/6 -

8

30

26.67%

0.002

30

30

100.00%

NA

5

CK5/6 - or 1+

18

30

60.00%

0.472

22

30

73.33%

0.007

6

Less CK5/6 staining in CC than in NBD

17

30

56.67%

0.337

  

NA

 

7

Cal+, and CK5/6 - in Cal - cases

16

23

69.57%

 

23

23

100.00%

 
  1. Note: Cal: calretinin, CC: Cholangiocarcinoma, NBD: accompanying normal bile duct, NA: not applicable, *Comparison between criteria 7 and other criteria by using Pearson Chi-square test, #Comparison between criteria 7 and 5 by using Fischer’s exact test.