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Table 1 Treatments used in mast cell activation disease

From: Utility of hydroxyurea in mast cell activation syndrome

Mechanism of action

Therapies / therapeutic classes

Anti-mediator (inhibition of MC mediator production or action)

Histamine H1 receptor antagonists

Histamine H2 receptor antagonists

Non-steroidal anti-inflammatory drugs

Benzodiazepines

Corticosteroids

Leukotriene receptor antagonists

Proton pump inhibitors

Tricyclic antidepressants (antihistaminic)

Phenothiazines (antihistaminic)

Hydroxyurea

Bisphosphonates, vitamin D, calcium

5-hydroxytryptamine3 receptor antagonists

Ivabradine

Icatibant

Alpha lipoic acid

N-acetylcysteine

Amphetamines

Hypolipidemics

Mast cell stabilizers

Cromolyn

Quercetin

Ketotifen

Pentosan

Tyrosine kinase inhibitors

Alpha interferon

Vitamin C

Cytostatic/cytotoxic agents

Cladribine

Pentostatin

Fludarabine

Paclitaxel

Alkylators (e.g., cyclophosphamide)

Hydroxyurea

Immunomodulation

Allergy desensitization therapy

Allogeneic stem cell transplantation