From: Utility of hydroxyurea in mast cell activation syndrome
Mechanism of action | Therapies / therapeutic classes |
---|---|
Anti-mediator (inhibition of MC mediator production or action) | Histamine H1 receptor antagonists |
Histamine H2 receptor antagonists | |
Non-steroidal anti-inflammatory drugs | |
Benzodiazepines | |
Corticosteroids | |
Leukotriene receptor antagonists | |
Proton pump inhibitors | |
Tricyclic antidepressants (antihistaminic) | |
Phenothiazines (antihistaminic) | |
Hydroxyurea | |
Bisphosphonates, vitamin D, calcium | |
5-hydroxytryptamine3 receptor antagonists | |
Ivabradine | |
Icatibant | |
Alpha lipoic acid | |
N-acetylcysteine | |
Amphetamines | |
Hypolipidemics | |
Mast cell stabilizers | Cromolyn |
Quercetin | |
Ketotifen | |
Pentosan | |
Tyrosine kinase inhibitors | |
Alpha interferon | |
Vitamin C | |
Cytostatic/cytotoxic agents | Cladribine |
Pentostatin | |
Fludarabine | |
Paclitaxel | |
Alkylators (e.g., cyclophosphamide) | |
Hydroxyurea | |
Immunomodulation | Allergy desensitization therapy |
Allogeneic stem cell transplantation |