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Table 1 Treatments used in mast cell activation disease

From: Utility of hydroxyurea in mast cell activation syndrome

Mechanism of action Therapies / therapeutic classes
Anti-mediator (inhibition of MC mediator production or action) Histamine H1 receptor antagonists
Histamine H2 receptor antagonists
Non-steroidal anti-inflammatory drugs
Benzodiazepines
Corticosteroids
Leukotriene receptor antagonists
Proton pump inhibitors
Tricyclic antidepressants (antihistaminic)
Phenothiazines (antihistaminic)
Hydroxyurea
Bisphosphonates, vitamin D, calcium
5-hydroxytryptamine3 receptor antagonists
Ivabradine
Icatibant
Alpha lipoic acid
N-acetylcysteine
Amphetamines
Hypolipidemics
Mast cell stabilizers Cromolyn
Quercetin
Ketotifen
Pentosan
Tyrosine kinase inhibitors
Alpha interferon
Vitamin C
Cytostatic/cytotoxic agents Cladribine
Pentostatin
Fludarabine
Paclitaxel
Alkylators (e.g., cyclophosphamide)
Hydroxyurea
Immunomodulation Allergy desensitization therapy
Allogeneic stem cell transplantation