Figure 8

The multi-ABC transporter inhibitor reserpine increases the sensitivity of R001M early passage medulloblastoma cells to radiation. (A) Cells exposed to reserpine show reduced survival after high dose radiation exposure, by resazurin based total viability assay (error bars +/− 1 SD, n = 10). Asterisks above data points indicate p-values for 5 μM reserpine compared with control, asterisks below indicate significance for 10 μM (“*” p-value < 0.05, “**” < 0.01, “***” < 0.001). (B) Reserpine had no detectable toxicity at the highest dose used, as shown by resazurin fluorescence readings with and without drug in the absence of radiation (error bars +/− 1 SD).