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Table 3 Clearance * of tinzaparin after subcutaneous administration in healthy volunteers (summary of five published studies)

From: Tinzaparin and other low-molecular-weight heparins: what is the evidence for differential dependence on renal clearance?

Tinzaparin dose N (subjects) Mean AUC (h · IU/mL) Mean clearance (mL/min) Reference
4,500 IU or 50 IU/kg 12 1.35 37.0c [35]
30 1.96a 38.3c [39]
  2.35b 31.9c  
30 1.81 44.3d [12]
12,500 IU or 175 IU/kg 30 9.23 22.6c [39]
30 9.70 21.7c [37]
14 9.01 23.0d [38]
  1. aTinzaparin was formulated with preservative; bTinzaparin was formulated without preservative; cCl/F, calculated from data in the publication; dCl/F, published data.
  2. *Clearance was followed by measuring anti-Xa activity.