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Table 3 Clearance * of tinzaparin after subcutaneous administration in healthy volunteers (summary of five published studies)

From: Tinzaparin and other low-molecular-weight heparins: what is the evidence for differential dependence on renal clearance?

Tinzaparin dose

N (subjects)

Mean AUC (h · IU/mL)

Mean clearance (mL/min)

Reference

4,500 IU or 50 IU/kg

12

1.35

37.0c

[35]

30

1.96a

38.3c

[39]

 

2.35b

31.9c

 

30

1.81

44.3d

[12]

12,500 IU or 175 IU/kg

30

9.23

22.6c

[39]

30

9.70

21.7c

[37]

14

9.01

23.0d

[38]

  1. aTinzaparin was formulated with preservative; bTinzaparin was formulated without preservative; cCl/F, calculated from data in the publication; dCl/F, published data.
  2. *Clearance was followed by measuring anti-Xa activity.