Effect of MW and dose on the balance between renal and non-renal elimination of UFH and LMWH: amount of 125
I-UFH (circles) and 125
I-nadroparin (squares) cleared from the blood according to the dose delivered. The solid lines show the total elimination. The curves have been decomposed by drawing a parallel to its linear part: the stippled lines (a) represent the non-saturable mechanism of disappearance and the dotted lines (b) represent the saturable mechanism of disappearance for the two test articles (nadroparin and UFH). Adapted and reprinted from Thrombosis Research, Vol 46, Boneu B et al, The disappearance of a low molecular weight heparin fraction (CY 216) differs from standard heparin in rabbits, pages 845–853, copyright 1987, with permission from Elsevier .