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Table 3 OT interrupted the protein synthesis rates

From: Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells

Protein name

Protein synthesis rate

48 ( 15N only) g

50 μM OT (h)

12 h

48 i

Endoplasmin

71%

--j

42%

Heat shock cognate 71 kDa protein

65%

--

52%

Ribonuclease inhibitor

59%

--

36%

Annexin A1

55%

--

37%

Glyceraldehyde-3-phosphate dehydrogenase

61%

--

70%

Heterogeneous nuclear ribonucleoprotein F

63%

--

78%

Heterogeneous nuclear ribonucleoproteins A2/B1

67%

--

45%

Peroxiredoxin-4

65%

--

73%

Peroxiredoxin-6

70%

--

52%

  1. g. Protein turnover rates were measured from cells treated with 15 N enriched medium for 48 h without OT treatment.
  2. h. Protein turnover rates were measured from cells treated with 15 N enriched medium and 50 μM OT for 12 h.
  3. i. Protein turnover rates were measured from cells treated with 15 N enriched medium and 50 μM OT for 48 h.
  4. j. “--” means no significant changes of protein turnover rates compare to basal group (0 hr).