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Table 2 Identified proteins of differential expression of the MIA PaCa-2 cells in the OT-time dependent group by MALDI-TOF/TOF MS

From: Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells

Spot No. a Accession number b Protein name Ratio of OT-induced differential expression c
Total proteins Phosphorylated proteins
0 24 48 (h) 0 24 48 (h)
1 P49321e Nuclear autoantigenic sperm protein 1.00 0.37 1.35 1.00 0.09 0.05
2 P14625f Endoplasmin 1.00 1.17 0.26 -- -- --
3 Q14697 e Neutral alpha-glucosidase AB 1.00 0.41 0.89 -- -- --
4 P11142d Heat shock cognate 71 kDa protein 1.00 0.62 0.45 1.00 0.13 0.08
5 P29401 f Transketolase 1.00 3.23 0.77 -- -- --
6 P31948 d Stress-induced-phosphoprotein 1 1.00 0.61 0.28 1.00 1.17 0.19
7 P30101 d Protein disulfide-isomerase A3 1.00 0.30 0.06 -- -- --
8 P17987 d T-complex protein 1 subunit alpha 1.00 0.39 0.21 -- -- --
9 P31146 e Coronin-1A 1.00 0.45 0.74 -- -- --
10 P31943 d Heterogeneous nuclear ribonucleoprotein H 1.00 0.88 0.49 -- -- --
11 P07237 e Protein disulfide-isomerase 1.00 0.37 0.84 -- -- --
12 P13489 d Ribonuclease inhibitor 1.00 0.91 0.23 -- -- --
13 P27797 f Calreticulin 1.00 3.58 0.95 -- -- --
14 P06733 f Alpha-enolase 1.00 2.37 0.82 1.00 0.24 0.07
15 Q86VC0 f 40S ribosomal protein SA 1.00 1.35 2.00 -- -- --
16 P52597 e Heterogeneous nuclear ribonucleoprotein F 1.00 0.31 0.73 -- -- --
17 P52907 e F-actin-capping protein subunit alpha-1 1.00 0.49 0.81 -- -- --
18 O75821 e Eukaryotic translation initiation factor 3 subunit I 1.00 0.29 0.72 1.00 0.73 0.29
19 P47755 e F-actin-capping protein subunit alpha-2 1.00 0.43 0.87 1.00 0.20 0.03
20 P04083 d Annexin A1 1.00 0.87 0.48 -- -- --
21 P04406 e Glyceraldehyde-3-phosphate dehydrogenase 1.00 0.39 1.25 -- -- --
22 P04406 e Glyceraldehyde-3-phosphate dehydrogenase 1.00 0.41 1.32 -- -- --
23 P09651 e Heterogeneous nuclear ribonucleoprotein A1 1.00 0.17 1.39 -- -- --
24 P22626 e Heterogeneous nuclear ribonucleoproteins A2/B1 1.00 0.06 0.33 -- -- --
25 P52895 e Aldo-keto reductase family 1 member C2 1.00 0.48 4.02 -- -- --
26 Q9BYE2 d Serine/threonine-protein kinase 13 1.00 0.11 0.07 -- -- --
27 P08758 d Annexin A5 1.00 0.43 0.36 -- -- --
28 Q9Y275 d 14-3-3 protein epsilon 1.00 0.34 0.12 1.00 0.36 0.15
29 P31946 d 14-3-3 protein beta/alpha 1.00 0.39 0.22 1.00 0.31 0.74
30 P63104 d 14-3-3 protein zeta/delta 1.00 0.42 0.28 1.00 0.87 0.14
31 P56537 e Eukaryotic translation initiation factor 6 1.00 0.39 0.47 1.00 0.76 0.41
32 P62258 f Tumor necrosis factor ligand superfamily member 13B 1.00 2.13 0.29 1.00 0.33 0.17
33 Q6ZU15 e Septin-14 1.00 0.04 0.78 -- -- --
34 Q13162 e Peroxiredoxin-4 1.00 0.20 0.53 -- -- --
35 P18669 e Phosphoglycerate mutase 1 1.00 0.08 2.59 -- -- --
36 P63244 e Guanine nucleotide-binding protein subunit beta-2-like 1 1.00 0.49 0.91 -- -- --
37 P04792 d Heat shock protein beta-1 1.00 0.43 0.28 -- -- --
38 P30041 d Peroxiredoxin-6 1.00 0.89 0.37 -- -- --
39 P09211 d Glutathione S-transferase P 1.00 0.77 0.42 1.00 0.26 0.04
40 P16949 e Stathmin 1.00 0.35 0.46 -- -- --
41 P15531 d Nucleoside diphosphate kinase A 1.00 0.97 0.09 -- -- --
42 P32119 e Peroxiredoxin-2 1.00 0.37 0.49 -- -- --
43 P60660 d Myosin light polypeptide 6 1.00 0.88 0.23 -- -- --
44 Q8N1F1f Putative uncharacterized protein NCRNA00188 1.00 1.15 0.50 -- -- --
45 P05109 e Protein S100-A8 1.00 0.29 0.73 -- -- --
46 P62937 e Peptidyl-prolyl cis-trans isomerase A 1.00 0.07 0.19 -- -- --
47 Q969J3 Loss of heterozygosity 12 chromosomal region 1 protein -- -- -- 1.00 0.13 0.02
48 P63241 Eukaryotic translation initiation factor 5A-1 -- -- -- 1.00 0.14 0.05
  1. a. The numbers of the identified protein spots are indicated in Figures 1, 2, and 3;
  2. b. Swiss-Prot/TrEMBL primary accession number.
  3. c. The ratio of expression level (intensity on the gel) of each protein spot were calculated based on the control (0 μM OT) group.
  4. d. Protein expression in Cluster 1.
  5. e. Protein expression in Cluster 2.
  6. f. Protein expression in Cluster 3.