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Table 1 Identified proteins of differential expression of the MIA PaCa-2 cells in the OT-dose dependent group by MALDI-TOF/TOF MS

From: Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells

Spot No. a Accession number b Protein name Ratio of OT-induced differential expression c
0 5 50 500 (μM)
1 P14625 Endoplasmin 1 0.27 0.33 0.20
2 P11142 Heat shock cognate 71 kDa protein 1 0.41 025 0.19
3 P11142 Heat shock cognate 71 kDa protein 1 3.13 2.58 2.79
4 P13639 Elongation factor 2 1 0.13 0.09 0.21
5 P08238 Heat shock protein HSP 90-beta 1 0.26 0.18 0.14
6 P07237 Protein disulfide-isomerase 1 0.07 0.22 0.09
7 P13489 Ribonuclease inhibitor 1 0.17 0.24 0.19
8 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 1 7.51 11.45 10.96
9 P63244 Guanine nucleotide-binding protein subunit beta-2-like 1 1 0.65 0.43 0.38
10 Q15056 Eukaryotic translation initiation factor 4H 1 0.32 0.15 0.27
11 P56537 Eukaryotic translation initiation factor 6 1 0.40 0.24 0.17
12 P09211 Glutathione S-transferase P 1 0.61 0.57 0.26
13 P30086 Phosphatidylethanolamine-binding protein 1 1 0.63 0.29 0.3
14 P62826 GTP-binding nuclear protein Ran 1 0.37 0.42 0.15
15 P60660 Myosin light polypeptide 6 1 0.34 0.49 0.08
16 P51854 Transketolase 1 4.17 3.30 1.85
17 Q6GMP2 Alpha-enolase 1 0.89 2.13 2.29
18 P31946 14-3-3 protein beta/alpha 1 0.76 0.50 0.55
  1. a. The numbers of the identified protein spots are indicated in Figures 1, 2 and 3;
  2. b. Swiss-Prot/TrEMBL primary accession number.
  3. c. The ratio of expression level (intensity on the gel) of each protein spot were calculated based on the control (0 μM OT) group.
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Experimental Hematology & Oncology

ISSN: 2162-3619

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