Figure 4

Functional characteristics of the differential proteins identified. A. Functional analysis of fifty-two differential proteins via Ingenuity database (http://www.ingenuity.com). Molecular functional annotation including cell death (29, 37.7%), gene expression (12, 15.6%), post-translational modification (14, 18.2%), cell-to-cell signaling and interaction (11, 14.3%), protein folding (5, 6.5%), protein trafficking (6, 7.8%). B. Classification related with diseases and disorders including cancer (28, 24.3%), reproductive system disease (17, 14.8%), gastrointestinal disease (12, 10.4%), hematological disease (12, 10.4%), immunological disease (16, 13.9%), inflammatory disease (19, 16.5%), respiratory disease (11, 9.6%). C. The analysis of network based on the Ingenuity database. A total of 36 differential proteins, which showed three different profiles response to OT treatment, were matched in the signaling network of cancer and cell death.