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Table 3 In vivo tumorigenicity assay of FACS sorted CD133 high and CD133 dim LC-42 cells at different injected cell doses in NOD/SCID mice

From: In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines

Group

Cell type

Number of the cells injected

Number of the mice with tumor/ number of the mice injected

Latency

No.

injected

1

CD133high

1×103

3/3

6W

2

CD133dim

1×103

3/3

6W

3

CD133high

1×104

3/3

5W

4

CD133dim

1×104

3/3

5W

5

CD133high

1×105

5/5

3W

6

CD133dim

1×105

5/5

3W

7

CD133high

1×106

3/3

2W

8

CD133dim

1×106

3/3

2W

1

Unsorted cells

1×105

3/3

3W

2

Unsorted cells

2×105

3/3

3W

3

Unsorted cells

2×106

3/3

2W

4

Unsorted cells

5×106

6/6

2W

  1. Comparison of xenograft formation in NOD/SCID mice with different numbers of injected CD133high and CD133dim cells. Both FACS isolated CD133high and CD133dim LC-42 cells were 100% tumorigenic in NOD/SCID mice at different injected cell dose even only 1×103 cells were injected. Unsorted LC-42 cells were established as control groups.