Skip to main content
Figure 2 | Experimental Hematology & Oncology

Figure 2

From: Vincristine could partly suppress stromal support to T-ALL blasts during pegylated arginase I treatment

Figure 2

Apoptosis of T-ALL cell line treated with or without BCT-100 under stromal support/culture alone. (a) CCRF-CEM, Jurkat or MOLT-4 cell lines were cultured for 36 hours with or without hMSCs or hTertMSCs transwell co-culture. Annexin V / FITC Propidium iodide (AV/PI) assay was performed to test the percentage of apoptosis. (b) CCRF-CEM, Jurkat or MOLT-4 cell lines were treated with 1 U/ml BCT-100 for 36 hours with or without transwell co-culture with hMSCs or hTertMSCs. AV/PI assay was performed to test the percentage of apoptosis. The average apoptotic percentages of the 3 T-ALL cell lines were significantly increased but such effect was partly attenuated by co-culturing with hTertMSCs and hMSCs from different donors. All experiments were done in triplicate and error bars showed respective standard deviation. *: p < 0.05 between T-ALL / hMSCs co-culture and T-ALL culture alone. **: p < 0.01 between T-ALL / hMSCs co-culture and T-ALL culture alone.

Back to article page