Table 1 Clinical and immunophenotypic features of T-ALL patients at diagnosis according to expression of miR-221 and miR-374

Age¹, years

22.8 (1 – 66)

17.4 (2 – 44)

0.22

23.6 (1 – 66)

16.8 (2 – 44)

0.49

Gender (M/F)

24(18/6)

24 (21/3)

0.46

24(21/3)

23(17/6)

0.12

Mediastinal mass (%)

14/24(58)

6/24 (25)

0.15

15/24 (62.5)

5/23(22)

0.13

Lymphadenopathy (%)

15/24(62.5)

21/24 (87.5)

0.26

16/24 (67)

19/23(83)

0.24

Splenomegaly (%)

16/24(67)

16/24 (67)

0.66

17/24 (71)

14/23(61)

0.6

Hepatomegaly (%)

15/24(62.5)

16/24 (67)

0.99

17/24 (71)

13/23(56.5)

0.44

CNS involvement (%)

1/24(4)

2/24 (8)

0.56

2/24 (8)

1/23(4)

0.53

Blasts BM¹ (%)

77.3 (20 – 100)

90.5 (28 – 100)

0.09

77.6 (20 – 100)

90.7 (28 – 100)

0.64

Blasts PB¹ (%)

63.4 (0 – 100)

78.5 (10 – 100)

0.18

61.5 (0 – 100)

86 (10 – 100)

0.45

Hemoglobin¹ (g/l)

10.4 (3.6 – 15.6)

10.4 (4.6 – 17.1)

0.97

10.1 (3.6 – 15.8)

10.8 (5.3 – 17.1)

0.4

WBC¹ count × 10⁹/l

104 (4.6 – 314)

202.3 (4.5 – 790)

0.06

118 (4.5 – 781)

196 (18 – 789)

0.61

Platelets¹ × 10⁹/l

149.4 (9 – 652)

48.8 (9 – 185)

0.009*

140 (9 – 652)

55.8 (9 – 231)

0.03*

Pre thymic (%)

7/24(29)

4/24(17)

0.31

6/24 (25)

5/23(22)

0.81

Thymic (%)

7/24(29)

10/24(42)

0.54

9/24 (37.5)

7/23(30)

0.51

Mature T (%)

8/24(33)

8/24(33)

0.98

7/24 (29)

9/23(39)

0.37

CD34 (%)

16/24(67)

8/24(33)

0.042*

13/24 (54)

11/23(48)

0.56

CD56 (%)

11/24(46)

1/24(4)

0.001*

12/24 (50)

1/23(4)

<0.001*

TdT (%)

18/24(75)

21/24(87)

0.46

17/24 (71)

21/23(91)

0.28