Figure 1

Quantitative analysis of miR-221 (A) and miR-374 (B) expression in samples from T-ALL patients, T-cells from normal peripheral blood, and CD3⁺ /CD4⁺ /CD8⁺ thymocytes. Leukemic samples from 48 T-ALL patients were obtained from cell banks. The expression of miRNAs was quantified by Real-Time Quantitative PCR (RQ-PCR). The horizontal bars represent the mean of miRNA expression calculated by 2^-ΔCt. T-ALL samples were categorized according to presence of the CD56 cell marker: 12 samples were positive (T-ALL/CD56⁺) and 36 were negative (T-ALL/CD56^-). Asterisks indicate significant differences between groups (ANOVA test followed by a Dunn’s post-test).