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Figure 1 | Experimental Hematology & Oncology

Figure 1

From: Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse

Figure 1

A. Bone marrow smear at diagnosis from the first patient at two different magnifications. The marrow shows increased cellularity by round-shaped medium-sized blasts with basophilic occasionally vacuolated sparsely granulated cytoplasm and perinuclear halos. The nuclei show 1-3 nucleoli. Peroxidase stain: 10% positive, esterase stain: 100% markedly positive, PAS stain: approx. 50% granular positive. The cytomorphology is compatible with the diagnosis of AML FAB M5a. B. Bone marrow smear at the time of relapse from the second patient at two different magnifications. The marrow shows an overall normal cellularity and is infiltrated by heterogenous blasts displaying oval or bean-shaped nuclei with prominent nucleoli and a moderately abundant partially granulated cytoplasm. Peroxidase stain: 20% of blasts positive, esterase stain negative. The cytomorphology is compatible with the diagnosis of AML FAB M2.

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