Table 1 Patient characteristics (N=38)
Patient characteristics | Number (%) |
|---|---|
Gender: male/female | 22/16 (58%/42%) |
Median age at diagnosis, years (range) | 4 (0-16) |
Median age at clofarabine treatment onset, years (range) | 7 (0-18) |
WBC count at diagnosis x109/l (range) | 7.45 (0.9-675) |
Immunophenotype | |
B lineage | 33 (87%) |
T lineage | 2 (5%) |
Biphenotypic | 3 (8%) |
CNS involvement at diagnosis | 2 |
Adverse cytogenetics | |
t(4;11) | 1 |
Hypodiploid karyotype | 2 |
First line protocol | |
FRALLE 2000 | 17 |
EORTC 58951 | 17 |
ELAM 02 | 1 |
Interfant 2006 | 3 |
Refractory to initial treatment | 0 |
Number of earlier therapies, mean (range) | 2.5 (1-4) |
Previous hematopoietic stem-cell transplantation | 10 |