Skip to main content

Table 1 Summary of all patients with intravascular lymphomatosis limited to the CNS (cIVL) reported in the literature

From: Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy

Author

Site of involvement

Neurological symptoms

Treatment

Outcome

Baehring et al. [1]

Brain

Right hemiparesis, dysarthria

HD-MTX (induction 5, consolidation 10, maintenance 2)

CR 20 months after diagnosis

Baehring et al. [1]

Brain, spinal cord

Proximal spastic paraparesis, psychosis

HD-MTX (induction 12)

PR 18 months after diagnosis

Baehring et al. [1]

Brain, nerve roots

Dysarthria, gait disturbance, allodynia

HD-MTX initially (induction 6, consolidation 4), HD-MTX salvage (6 induction, 7 consolidation)

PR until 8 months after diagnosis: PR until 12 months after recurrence

Baehring et al. [1]

Brain

Cognitive decline, homonymous hemianopsia, ataxia

HD-MTX (induction 1 cycle)

Died of disease progression after first cycle of chemotherapy

Calamia et al. [15]

CNS

NA

m-BACOD

OS 16 months

Calamia et al. [15]

CNS

NA

Pro-MACE-CytaBOM

OS 44 months

Bergmann et al. [6]

Brain

Left-sided hemiparesis

NA

OS 2 months

Bergmann et al. [6]

Brain

Spastic paraparesis, left arm paresis

NA

OS 2 months

DiGiuseppe et al. [3]

Brain

Mental status changes

Pro-MACE-CytaBOM, ifosfamide/VP-16/cisplatin & whole brain irradiation (45 Gy)

CR 48 months after diagnosis

Kanda et al. [16]

CNS

Aphasia, apraxia

CHOP, VEMP, radiotherapy

OS one month

Aznar et al. [7]

CNS

Distal paresthesia of the lower limbs, paraparesis

NA

OS few months

Passarin [8]

Brain

Progressive cognitive deterioration, tetraparesis

NA

OS 3–4 weeks

Natali-Sora et al. [17]

CNS

Generalized tonic-clonic seizures

Cyclophosphamide, mitoxantrone, BCNU, methylprednisolone

CR 46 months after diagnosis

Liow et al. [18]

CNS

NA

CHOP

OS 13 months

Albrecht et al. [9]

Brain

Cognitive deterioration, aphasia

NA

OS few weeks

Ferreri et al. [10]

CNS

NA

CHOP (3 patients), CVP (one patient)

OS less than 4 months

Holmøy et al. [12]

Brain

vertigo, diplopia, left-sided hearing loss, aphasia

high-dose corticosteroid pulse therapy

OS 18 weeks

Momota et al. [14]

Brain

Left-sided hemiparesis

HD-MTX, whole brain irradiation

OS 6 months

This case

Brain

Transient amnestic aphasia, gait ataxia

Bonn protocol + rituximab

CR 29 months after diagnosis

  1. Abbreviations: HD-MTX: high dose methotrexate; CR: complete remssion; PR: partial response; NA: not available; OS: overall survival; m-BACOD: cyclophosphamide, doxorubicin, vincristine, bleomycin, dexamethasone, methotrexate; Pro-MACE-CytaBOM: prednisone, methotrexate (with leucovorin rescue), doxorubicin, cyclophosphamide, etoposide, cytarabine, bleomycin, vincristine; VP-16: etoposide; CHOP: cyclophosphamide, doxorubicin, vincristine, prednisolone; VEMP: vincristine, cyclophosphamide, mercaptopurine, prednisolone; CVP: cyclophosphamide, vincristine and prednisone; Bonn protocol: HD-MTX, ifosfamide, procarbazin, cytarabine, vinca alkaloids, dexamethasone.