From: Intravascular CNS lymphoma: Successful therapy using high-dose methotrexate-based polychemotherapy
Author | Site of involvement | Neurological symptoms | Treatment | Outcome |
---|---|---|---|---|
Baehring et al. [1] | Brain | Right hemiparesis, dysarthria | HD-MTX (induction 5, consolidation 10, maintenance 2) | CR 20 months after diagnosis |
Baehring et al. [1] | Brain, spinal cord | Proximal spastic paraparesis, psychosis | HD-MTX (induction 12) | PR 18 months after diagnosis |
Baehring et al. [1] | Brain, nerve roots | Dysarthria, gait disturbance, allodynia | HD-MTX initially (induction 6, consolidation 4), HD-MTX salvage (6 induction, 7 consolidation) | PR until 8 months after diagnosis: PR until 12 months after recurrence |
Baehring et al. [1] | Brain | Cognitive decline, homonymous hemianopsia, ataxia | HD-MTX (induction 1 cycle) | Died of disease progression after first cycle of chemotherapy |
Calamia et al. [15] | CNS | NA | m-BACOD | OS 16 months |
Calamia et al. [15] | CNS | NA | Pro-MACE-CytaBOM | OS 44 months |
Bergmann et al. [6] | Brain | Left-sided hemiparesis | NA | OS 2 months |
Bergmann et al. [6] | Brain | Spastic paraparesis, left arm paresis | NA | OS 2 months |
DiGiuseppe et al. [3] | Brain | Mental status changes | Pro-MACE-CytaBOM, ifosfamide/VP-16/cisplatin & whole brain irradiation (45 Gy) | CR 48 months after diagnosis |
Kanda et al. [16] | CNS | Aphasia, apraxia | CHOP, VEMP, radiotherapy | OS one month |
Aznar et al. [7] | CNS | Distal paresthesia of the lower limbs, paraparesis | NA | OS few months |
Passarin [8] | Brain | Progressive cognitive deterioration, tetraparesis | NA | OS 3–4 weeks |
Natali-Sora et al. [17] | CNS | Generalized tonic-clonic seizures | Cyclophosphamide, mitoxantrone, BCNU, methylprednisolone | CR 46 months after diagnosis |
Liow et al. [18] | CNS | NA | CHOP | OS 13 months |
Albrecht et al. [9] | Brain | Cognitive deterioration, aphasia | NA | OS few weeks |
Ferreri et al. [10] | CNS | NA | CHOP (3 patients), CVP (one patient) | OS less than 4 months |
Holmøy et al. [12] | Brain | vertigo, diplopia, left-sided hearing loss, aphasia | high-dose corticosteroid pulse therapy | OS 18 weeks |
Momota et al. [14] | Brain | Left-sided hemiparesis | HD-MTX, whole brain irradiation | OS 6 months |
This case | Brain | Transient amnestic aphasia, gait ataxia | Bonn protocol + rituximab | CR 29 months after diagnosis |