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Table 1 Pharmacokinetics of the IMiDs

From: Thalidomide and its analogues in the treatment of Multiple Myeloma

Drug

Route of administration

Dosage

Metabolism/Excretion

Half-life

Dose adjustments

Thalidomide

Oral

50-100 mg

Hepatic/Non-renal

4-9 hours

None at present

Lenalidomide (CC-5013)

Oral

15-25 mg

Renal (67% unchanged)

3.1-4.5 hours

Adjust for moderate to severe renal impairment

Pomalidomide (CC-4047)

Oral

1-5 mg

Renal (67% unchanged)

6.2-7.9 hours

None at present