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Table 1 Effect of eculizumab on liver function

From: Eculizumab in paroxysmal nocturnal hemoglobinuria with Budd-Chiari syndrome progressing despite anticoagulation

Days post-eculizumab Laboratory value (normal range)
  LDH Platelets Hemoglobin AST ALT Bilirubin total Bilirubin D Cholinesterase Albumin
  U/L × 10 9/L g/dL U/L U/L mg/dL mg/dL U/L g/dL
  (≤480) (150–400) (14–18) (≤40) (≤37) (0.2–1.3) (<0.3) (>4400) (3.5–5.0)
-68 1836 34 9.2 63 78 3.6 1.7 3572
-33 921 27 9.8 49 70 2.4 0.9 2889 3.47
0 (1st dose) 23 10.7 36 24 3.3 1.4
7 519 53 9.7 20 18 2.3 1 3.54
14 368 57 10.3 15 14 1.9 0.7
56 565 80 9.6 28 9 2.2 1 5135 3.6
119 248 53 9.9 16 8 1.7 0.8 5975
202 295 94 11.3 25 20 2.1 0.9 6968 4.52
300 344 62 10.3 28 25 1.6 0.6 7603 4.68
365 298 58 10.2 22 19 1.6 0.7 4.27
449 354 69 11.3 26 26 1.9 0.8 7704 5.1
547 340 63 12 25 24 1.6 0.6 7852 4.73
631 285 73 11.6 26 27 1.8 0.7 8360
743 351 65 11.5 26 23 1.7 0.7 8294 4.46
827 388 64 11.2 26 22 1.4 0.6
921 423 77 12.6 28 25 1.9 0.6 4.49
  1. ALT, alanine aminotransferase; AST, aspartate aminotransferase.