Table 1 Effect of eculizumab on liver function
Days post-eculizumab | Laboratory value (normal range) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
LDH | Platelets | Hemoglobin | AST | ALT | Bilirubin total | Bilirubin D | Cholinesterase | Albumin | |
U/L | × 10 9/L | g/dL | U/L | U/L | mg/dL | mg/dL | U/L | g/dL | |
(≤480) | (150–400) | (14–18) | (≤40) | (≤37) | (0.2–1.3) | (<0.3) | (>4400) | (3.5–5.0) | |
-68 | 1836 | 34 | 9.2 | 63 | 78 | 3.6 | 1.7 | 3572 | ─ |
-33 | 921 | 27 | 9.8 | 49 | 70 | 2.4 | 0.9 | 2889 | 3.47 |
0 (1st dose) | ─ | 23 | 10.7 | 36 | 24 | 3.3 | 1.4 | ─ | ─ |
7 | 519 | 53 | 9.7 | 20 | 18 | 2.3 | 1 | ─ | 3.54 |
14 | 368 | 57 | 10.3 | 15 | 14 | 1.9 | 0.7 | ─ | ─ |
56 | 565 | 80 | 9.6 | 28 | 9 | 2.2 | 1 | 5135 | 3.6 |
119 | 248 | 53 | 9.9 | 16 | 8 | 1.7 | 0.8 | 5975 | ─ |
202 | 295 | 94 | 11.3 | 25 | 20 | 2.1 | 0.9 | 6968 | 4.52 |
300 | 344 | 62 | 10.3 | 28 | 25 | 1.6 | 0.6 | 7603 | 4.68 |
365 | 298 | 58 | 10.2 | 22 | 19 | 1.6 | 0.7 | ─ | 4.27 |
449 | 354 | 69 | 11.3 | 26 | 26 | 1.9 | 0.8 | 7704 | 5.1 |
547 | 340 | 63 | 12 | 25 | 24 | 1.6 | 0.6 | 7852 | 4.73 |
631 | 285 | 73 | 11.6 | 26 | 27 | 1.8 | 0.7 | 8360 | ─ |
743 | 351 | 65 | 11.5 | 26 | 23 | 1.7 | 0.7 | 8294 | 4.46 |
827 | 388 | 64 | 11.2 | 26 | 22 | 1.4 | 0.6 | ─ | ─ |
921 | 423 | 77 | 12.6 | 28 | 25 | 1.9 | 0.6 | ─ | 4.49 |