Figure 4
From: JAK2V617F and p53 mutations coexist in erythroleukemia and megakaryoblastic leukemic cell lines
Potential deleterious effects of the M133K and R248W mutations on structure and function of p53. The upper panel shows a schematic diagram of p53 structure with the relative positions of the M133K and R248W mutation sites indicated. The lower panel demonstrates the crystal structure of the DNA binding domain of p53 in complex with DNA. Side chains for M133 (green) and R248 (red) are shown as balls and sticks, while the rest of the amino acid residues are represented in the backbone by ribbons.