Fig. 6From: Exploring the role of histone deacetylase and histone deacetylase inhibitors in the context of multiple myeloma: mechanisms, therapeutic implications, and future perspectivesMechanistic illustration of HDAC6 in STAT3-PD-L1 pathway: When HDAC6 levels are high, STAT3 accumulates in a phosphorylated form, reducing the interaction between STAT3 and PP2A. After entering the nucleus, pSTAT3 and HDAC6 bind to the PD-L1 promoter, promoting PD-L1 expression. Figure created with BioRender.comBack to article page