Fig. 5
From: Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion
MDSCs in lung cancer. MDSCs inhibit the function and differentiation of T and B cells by depleting arginine and IL-7 in lung cancer. In addition, stimulated by the overexpression of the cytokines IL-6, PTGES, PGE2 and CXC in lung cancer cells, MDSCs are recruited to the TME, where they help tumors escape immune surveillance. Meanwhile, both PDH and ROS upregulation caused by LAL reduction in MDSCs suppressed immune function