Fig. 3From: Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasionMDSCs in cutaneous melanoma. In melanoma, MDSCs differentiate from monocytes through the action of HSP90α on EVs secreted by tumor cells. In addition, MDSCs are stimulated by secreted IL-1β, IL-6, CCL2, CXCL1 and CXCL5 or induced by tumor cells; proliferate, activate and are recruited to the tumor site, where they in turn exert immunosuppressive effectsBack to article page