Fig. 2
From: Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion
MDSCs interactions with immune cells. MDSCs inhibit T-cell activity through several mechanisms, including impairment of T-cell homing, generation of oxidative stress, depletion of amino acids needed for T-cell responses, and expression of negative immune checkpoint molecules. In addition, MDSCs crosstalk with other immune cells to exert immunosuppressive effects. These include tumor-killing immune cells, such as natural killer (NK) cells and DCs, and immunosuppressive macrophages and regulatory T cells (Tregs). As an important component of the tumor microenvironment, the interaction between MDSCs and CAFs is also critical for tumor development