Fig. 1
From: Novel insights into TCR-T cell therapy in solid neoplasms: optimizing adoptive immunotherapy
Schematic diagram of TCR/CD3 and peptide-MHC structure. Cancer cells process and deliver intracellular antigenic peptides via MHC class I molecules on the cell membrane. The TCR complex is essentially an α, β-double-stranded heterodimer, recognizing the peptide-MHC complex with the CD3 γε heterodimer, CD3 δε heterodimer and CD3 ζζ homodimer cooperatively