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Fig. 7 | Experimental Hematology & Oncology

Fig. 7

From: VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses

Fig. 7

VISTA surface expression on monocytes/macrophages and lymphocytes. (A) Representative flow cytometry diagram demonstrating surface expression of VISTA on CD14+ monocytes from non-Hodgkin or Hodgkin lymphoma patient PBMCs and healthy PBMCs. (B) Comparison of VISTA expression on CD14+ monocytes from non-Hodgkin or Hodgkin lymphoma (NHL/HL) patient PBMCs and healthy PBMCs (left panel). Sunburst plots of percent of donors with VISTA expression on CD14+ monocytes (inner ring) and CD3+ lymphocytes (outer ring) in NHL/HL patient PBMCs and healthy PBMCs (right panel). (C) Expression level of VISTA on CD14+ monocytes from NHL/HL patient PBMCs and healthy PBMCs. (D) Expression level of VISTA on VISTA+ CD14+ monocytes and M0-like, M1-like, and M2-like macrophages. **P < 0.01 and ***P < 0.001 by one-way ANOVA with post hoc intergroup comparisons using Tukey’s test

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