Table 4 Elimination of colorectal CSCs based on adoptive cell therapy
Type | Target | Action | References |
|---|---|---|---|
CTL | OR7C1 ASB4 CEP55 | Effective recognition and killing of colorectal CSCs | [273] [274] [275] |
CAR-T | EpCAM CD133 DCLK1 Lgr5 | Recognition and killing of colorectal CSCs without antigen presentation by MHC-I molecules | [279] [281] |
CAR-NK | EpCAM | EpCAM-specific CAR-NK can effectively recognize and kill colorectal CSCs Combined with regorafenib to exert a stronger anti-tumor effect | [286] |